[A2][a2b2]
- Classes: All alpha proteins
- Folds: Nuclear receptor ligand-binding domain
- Superfamilies: Nuclear receptor ligand-binding domain
- Families: Nuclear receptor ligand-binding domain
- Protein Domains: Androgen receptor
- Species: Human (Homo sapiens) [TaxId: 9606]
PDB Entries
| PDB ID | OPM | Mutant | Chain Formula | Resolution | HETNAM | ||
|---|---|---|---|---|---|---|---|
| Amino Acid sequence | SCOPe Family Level | CATH Homology Level | |||||
| 1e3g | [A] | [A] | [A] | 2.4 | R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE | ||
| 1gs4 |  |
[A] | [A] | [A] | 1.95 | PO4:PHOSPHATE ION ZK5:9ALPHA-FLUOROCORTISOL | |
| 1t5z | [A][a] | [A][a] | [A][a] | 2.3 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 1t63 | [A][a] | [A][a] | [A][a] | 2.07 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 1t65 | [A][a] | [A][a] | [A][a] | 1.66 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 1xow | [A][a] | [A][a] | [A][a] | 1.8 | R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE | ||
| 1xq3 | [A] | [A] | [A] | 2.25 | R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE | ||
| 2am9 | [A] | [A] | [A] | 1.64 | DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE GOL:GLYCEROL SO4:SULFATE ION TES:TESTOSTERONE | ||
| 2ama | [A] | [A] | [A] | 1.9 | DHT:5-ALPHA-DIHYDROTESTOSTERONE SO4:SULFATE ION | ||
| 2amb | [A] | [A] | [A] | 1.75 | 17H:17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID GOL:GLYCEROL SO4:SULFATE ION | ||
| 2ao6 | [A][a] | [A][a] | [A][a] | 1.89 | R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE | ||
| 2ax6 | |
[A] | [A] | [A] | 1.5 | HFT:HYDROXYFLUTAMIDE | |
| 2ax7 | |
[A] | [A] | [A] | 1.9 | FHM:S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | |
| 2ax8 | |
[A] | [A] | [A] | 1.7 | FHM:S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | |
| 2ax9 | [A] | [A] | [A] | 1.65 | BHM:(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | ||
| 2axa | [A] | [A] | [A] | 1.8 | FHM:S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | ||
| 2hvc | [A] | [A] | [A] | 2.1 | LGD:6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE | ||
| 2oz7 | |
[A] | [A] | [A] | 1.8 | CA4:CYPROTERONE ACETATE | |
| 2pio | [A] | [A] | [A] | 2.03 | 2MI:2-METHYL-1H-INDOLE DHT:5-ALPHA-DIHYDROTESTOSTERONE SO4:SULFATE ION | ||
| 2pip | [A] | [A] | [A] | 1.8 | DHT:5-ALPHA-DIHYDROTESTOSTERONE ICO:1H-INDOLE-3-CARBOXYLIC ACID K10:1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE SO4:SULFATE ION | ||
| 2piq | [A] | [A] | [A] | 2.4 | DHT:5-ALPHA-DIHYDROTESTOSTERONE RB1:3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL SO4:SULFATE ION | ||
| 2pir | [A] | [A] | [A] | 2.1 | DHT:5-ALPHA-DIHYDROTESTOSTERONE NK:SALICYLALDEHYDE SO4:SULFATE ION | ||
| 2pit | [A] | [A] | [A] | 1.76 | 4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETICACID DHT:5-ALPHA-DIHYDROTESTOSTERONE SO4:SULFATE ION | ||
| 2piu | [A] | [A] | [A] | 2.12 | 4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETICACID DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 2piv | [A] | [A] | [A] | 1.95 | DHT:5-ALPHA-DIHYDROTESTOSTERONE SO4:SULFATE ION T3:3,5,3___sq___TRIIODOTHYRONINE | ||
| 2piw | [A] | [A] | [A] | 2.58 | DHT:5-ALPHA-DIHYDROTESTOSTERONE T3:3,5,3___sq___TRIIODOTHYRONINE | ||
| 2pix | [A] | [A] | [A] | 2.4 | DHT:5-ALPHA-DIHYDROTESTOSTERONE FLF:2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID | ||
| 2pkl | [A][a] | [A][a] | [A][a] | 2.49 | 4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETICACID DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 2pnu | [A] | [A] | [A] | 1.65 | DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE ENM:(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID SO4:SULFATE ION | ||
| 2q7i | [A][a] | [A][a] | [A][a] | 1.87 | GOL:GLYCEROL SO4:SULFATE ION TES:TESTOSTERONE | ||
| 2q7j | [A][a] | [A][a] | [A][a] | 1.9 | GOL:GLYCEROL SO4:SULFATE ION TES:TESTOSTERONE | ||
| 2q7k | |
[A][a] | [A][a] | [A][a] | 1.8 | GOL:GLYCEROL SO4:SULFATE ION TES:TESTOSTERONE | |
| 2q7l | |
[A][a] | [A][a] | [A][a] | 1.92 | GOL:GLYCEROL TES:TESTOSTERONE | |
| 2yhd | [A] | [A] | [A] | 2.2 | AV6:4-(1H-PERIMIDIN-2-YL)BENZENE-1,2-DIOL SO4:SULFATE ION TES:TESTOSTERONE | ||
| 2z4j | [A][a] | [A][a] | [A][a] | 2.6 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 3b5r | [A] | [A] | [A] | 1.8 | B5R:(2S)-3-(4-CHLORO-3-FLUOROPHENOXY)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-2-HYDROXY-2-METHYLPROPANAMIDE | ||
| 3b65 | [A] | [A] | [A] | 1.8 | 3B6:(2S)-N-(4-CYANO-3-IODOPHENYL)-3-(4-CYANOPHENOXY)-2-HYDROXY-2-METHYLPROPANAMIDE | ||
| 3b66 | [A] | [A] | [A] | 1.65 | B66:4-{[(1R,2S)-1,2-DIHYDROXY-2-METHYL-3-(4-NITROPHENOXY)PROPYL]AMINO}-2-(TRIFLUOROMETHYL)BENZONITRILE | ||
| 3b67 | [A] | [A] | [A] | 1.9 | B67:(2S)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-3-(PENTAFLUOROPHENOXY)PROPANAMIDE | ||
| 3b68 | [A] | [A] | [A] | 1.9 | B68:(2S)-3-[4-(ACETYLAMINO)PHENOXY]-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | ||
| 3l3x | [A][a] | [A][a] | [A][a] | 1.55 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 3l3z | [A][a] | [A][a] | [A][a] | 2 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | ||
| 3rlj | [A] | [A] | [A] | 1.9 | RLJ:(2S)-3-(4-CYANOPHENOXY)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-2-HYDROXY-2-METHYLPROPANAMIDE | ||
| 3rll | |
[A] | [A] | [A] | 1.7 | RLL:(2S)-3-[(4-CYANONAPHTHALEN-1-YL)OXY]-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-2-HYDROXY-2-METHYLPROPANAMIDE | |
| 4hlw | [A] | [A] | [A] | 2.5 | 17W:2-[(2-PHENOXYETHYL)SULFANYL]-1H-BENZIMIDAZOLE GOL:GLYCEROL SO4:SULFATE ION TES:TESTOSTERONE | ||
| 4k7a | [A] | [A] | [A] | 2.44 | DHT:5-ALPHA-DIHYDROTESTOSTERONE MXD:6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE | ||
| 4oea | |
[A] | [A] | [A] | 2.12 | DHT:5-ALPHA-DIHYDROTESTOSTERONE | |
| 4ogh | |
[A] | [A] | [A] | 2.98 | HFT:HYDROXYFLUTAMIDE SO4:SULFATE ION | |
| 4oh5 | |
[A][a] | [A][a] | [A][a] | 2 | HFT:HYDROXYFLUTAMIDE SO4:SULFATE ION | |
| 4oha | |
[A][a] | [A][a] | [A][a] | 1.42 | HFT:HYDROXYFLUTAMIDE SO4:SULFATE ION | |
| 4oil | |
[A][a] | [A][a] | [A][a] | 2.51 | HFT:HYDROXYFLUTAMIDE | |
| 4oiu | |
[A][a] | [A][a] | [A][a] | 3.01 | HFT:HYDROXYFLUTAMIDE | |
| 4ojb | |
[A] | [A] | [A] | 2 | 198:R-BICALUTAMIDE | |
| 4ok1 | |
[A][a] | [A][a] | [A][a] | 2.09 | 198:R-BICALUTAMIDE | |
| 4okt | |
[A][a] | [A][a] | [A][a] | 2.5 | 198:R-BICALUTAMIDE | |
| 4okw | |
[A][a] | [A][a] | [A][a] | 2 | 198:R-BICALUTAMIDE | |
| 4okx | |
[A][a] | [A][a] | [A][a] | 2.1 | 198:R-BICALUTAMIDE SO4:SULFATE ION | |
| 4olm | |
[A][a] | [A][a] | [A][a] | 2.8 | 198:R-BICALUTAMIDE | |
| 4ql8 | [A] | [A] | [A] | 2.1 | JAD:2-CHLORO-4-[(3S,3AS,4S)-4-HYDROXY-3-METHOXY-3A,4,5,6-TETRAHYDRO-3H-PYRROLO[1,2-B]PYRAZOL-2-YL]-3-METHYLBENZONITRILE | ||
| 5jjm | [A2][a2b2] | [A2][a2b2] | [A2][a2b2] | 2.15 | ACT:ACETATE ION CL:CHLORIDE ION DHT:5-ALPHA-DIHYDROTESTOSTERONE EDO:1,2-ETHANEDIOL FME:N-FORMYLMETHIONINE GOL:GLYCEROL PGE:TRIETHYLENE GLYCOL SNC:S-NITROSO-CYSTEINE SO4:SULFATE ION ZN:ZINC ION | ||
| 5t8e | [A] | [A] | [A] | 2.71 | 77U:2-CHLORO-4-[(2S,3S)-3-HYDROXY-2-METHYLPYRROLIDIN-1-YL]-3-METHYLBENZONITRILE GOL:GLYCEROL | ||
| 5t8j | [A] | [A] | [A] | 2.7 | 77T:2-FLUORO-4-[(2S,3S)-3-HYDROXY-2,3-DIMETHYLPYRROLIDIN-1-YL]-3-METHYLBENZONITRILE GOL:GLYCEROL | ||
| 5v8q | [A] | [A] | [A] | 1.44 | 97A:4-[(2S,3S)-2-ETHYL-3-HYDROXY-5-OXOPYRROLIDIN-1-YL]-2-(TRIFLUOROMETHYL)BENZONITRILE GOL:GLYCEROL | ||
| 5vo4 | [A] | [A] | [A] | 2.35 | 9FG:5-(2-FLUORO-4-HYDROXYPHENYL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE | ||
*Chain Formula of OLIGAMI.
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
